Soothing and protecting the skin following minor skin irritations (itching, pain, and discomfort) Calamine lotion is a skin protectant. It works by soothing and protecting the skin. Direction to use: Shake well before using. Apply calamine lotion as often as necessary. A cotton pledget or soft cloth may be used for easy application. Do not apply calamine lotion over large areas of the body. If you miss using a dose of calamine lotion for 1 or more days, there is no cause for concern. If your doctor recommended that you use it, try to remember your dose every day.